• Akt mTOR signaling pathway is a

  2022-09-21

  

  Akt/mTOR signaling pathway is a major negative regulator of autophagy, via modulating ULK1 complex. It is well established that Inhibition of mTOR by deprivation of nutrients or growth factors, led to dephosphorylation of ULK1, ULK2, and Atg13 in human cells, which is a key step for ULK1 complex ass

• br G protein coupled receptor GPR also known

  2022-09-21

  

  G-protein coupled receptor 40 (GPR40), also known as a free fatty Tubastatin A HCl receptor, is dominantly expressed in pancreatic β cells and intestine K, L cells., . Besides, GPR40 is also reported to be expressed in brain, but its function is still unknown. It is well documented that GPR40 ago

• Recent research has focused on identifying

  2022-09-21

  

  Recent research has focused on identifying key agonists and receptors mediating nutrient-induced GLP-1 and insulin secretion. The long-chain fatty AH 7614 receptor GPR40 is the most abundant GPCR expressed in islet β cells and is also expressed on intestinal L-cells, where it contributes to GLP-1 r

• abt 737 Our previous study had shown that silencing

  2022-09-21

  

  Our previous study had shown that silencing FFAR1 expression weakened the action of PIO in increasing insulin secretion in lipotoxic β abt 737 [6]. Resent research found that PIO promoted insulin secretion by upregulating FFAR1 [17]. Therefore, we presumed that FFAR1 may be involved in the anti-lip

• br Materials and methods br Results and

  2022-09-21

  

  Materials and methods Results and discussion In order to identify genes required for photoautotrophic growth, we screened a random insertion mutant library of Synechocystis 6803 and obtained many mutants with impaired photoautotrophic growth. About 6000 random insertion colonies of the mutant

• Sirolimus rapamycin and everolimus both of which are

  2022-09-21

  

  Sirolimus (rapamycin) and everolimus, both of which are mTOR inhibitors, are released by commonly used first- and second-generation DES. Considering the relatively high rates of the target vessel failure with currently available DES [12,14,16,45,46], there is a need for a novel drug strategy that pr

• The lack of biological activity http www apexbt

  2022-09-21

  

  The lack of biological activity of this family of compounds against T. cruzi is quite unexpected and cannot be attributable simply to the presence of a hydroxyl group at C-1. In fact, either compound 6 or risedronate (5), both bearing a hydroxyl group at C-1, are effective inhibitors of TcFPPS.21, 2

• Although epigenetic mechanisms are implicated

  2022-09-20

  

  Although epigenetic mechanisms are implicated in the pathogenesis of hematopoietic malignancies, little is known about the role of lysine-specific histone demethylases and whether manipulation of these enzymes can be translated into targeted therapies. KDM6A is the most frequently mutated histone de

• The stable association of Hat complexes with histones H

  2022-09-20

  

  The stable association of Hat1 complexes with histones H3 and H4 raises a number of interesting issues. The first is the question of how Hat1 remains stably associated with histones H3 and H4. While the simple answer is that Hat1 remains bound to histones because of its association with histone chap

• br The HDC knockout mouse as a pathophysiological model

  2022-09-20

  

  The HDC knockout mouse as a pathophysiological model of TS The implication of a hypomorphic allele of the Hdc gene as a rare cause of TS (Ercan-Sencicek et al., 2010) created a rare opportunity for the generation of a pathophysiologically grounded model of the disorder. Modeling pathophysiology o

• The concentration of rapamycin that

  2022-09-20

  

  The concentration of rapamycin that gave half-maximal induction of the expression of HO-1 and Prx-1 mRNA in normal hepatocytes was 0.05 μM, with maximal induction at about 0.1 μM rapamycin. While, at rapamycin concentrations higher than 0.1 μM, the degree of enzyme induction decreased, elevated expr

• So studies are currently in progress

  2022-09-20

  

  So, studies are currently in progress to design drugs which could inhibit the main crosstalk components between interacting key pathways (Fig. 1). Wnt The Wnt family consists of 19 highly conserved glycoproteins serving as ligands which bind to the G-protein coupled 7-pass transmembrane receptor

• Here we used Drosophila and mouse models to address the

  2022-09-20

  

  Here, we used Drosophila and mouse models to address the biological function of RALs in the adult intestine. Our results demonstrate a conserved in vivo role for RALs in ISC function during tissue homeostasis and regeneration. ISCs lacking RALs were at a disadvantage compared to wild-type neighbors.

• KW 3902 Decreasing GSK activity has therapeutic benefits

  2022-09-20

  

  Decreasing GSK-3β activity has therapeutic benefits in animal model of colitis [45] and traumatic KW 3902 injury [46] and ischemia/reperfusion injury [47,48]. In brain, activation of GSK-3β promotes Aβ toxicity by elevating APP expression and its amyloidogenic cleavage, and by dysregulating Aβ clear

• br Introduction Activation of the lipid sensing

  2022-09-20

  

  Introduction Activation of the lipid sensing receptor, GPR55, by lysophosphatidyl inositol (LPI) has been well documented, and implicated in endocannabinoid signaling [1]. Intracellular events resulting from GPR55 activation include; enhanced β-arrestin activity, calcium mobilization and ERK1/2 p

15904 records 402/1061 page Previous Next First page 上5页 401402403404405 下5页 Last page